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زخم دیابتی
Non-healing chronic wounds, such as pressure, arterial, venous, and diabetic ulcers indefinitely remain in inflammation-the first stage of wound healing.
In recent years, there were ∼4.5, 9.7, and 10 million pressure, venous, and diabetic ulcer wound patients globally (MedMarket Diligence, 2012, 2015).
The numbers of pressure and venous ulcers are rising at rates of 6-7% annually, and growth is even larger for diabetic ulcers (9%) due to the increased incidence of diabetes in the developed world.
In fact, two thirds of all lower-limb amputations are due to diabetic ulcers (Sen et al.
, the total cost of diabetic ulcer care has also drastically increased in the past 20 years (Nussbaum et al.
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